CRISPR 기술, ‘약물로 공략하기 어려운’ 암을 포함해 암세포를 선택적으로 잘게 절단

This breakthrough demonstrates using CRISPR to selectively destroy cancer cells carrying tumor suppressor gene mutations—particularly p53—that have been undruggable with traditional small-molecule therapeutics. Unlike conventional gene editing that repairs defective proteins, this approach directly eliminates mutant cancer cells while sparing healthy ones, achieving single-nucleotide selectivity. This precision strategy bypasses chemotherapy's broad toxicity while enabling rapid development of new guide RNAs for emerging mutations, accelerating response cycles from years to months.