Advancing Clinical Genomics: Evaluating AI Tools for Variant Interpretation and Decision Support

This evaluation framework assesses critical AI tools—MedGemma, Nemotron RAG, and Kimi K2.5—for automating variant interpretation and clinical decision-making in genomic medicine. The findings demonstrate how GPU-accelerated AI systems can integrate into existing clinical workflows while maintaining accuracy and cost-effectiveness. This work is essential for bridging the gap between AI capabilities and the rigorous validation standards required for clinical adoption in precision medicine.